Open the carton, and there are two medicines inside, but only one of them is treating the cancer. Ifosfamide injection does that work, and the mesna traveling with it exists to protect the bladder from what ifosfamide leaves behind. Torso Healthcare supplies the 1 g vial with its mesna for hospitals, oncology distributors, and franchise partners who want the pack under their own brand.

What is ifosfamide injection?

Ifosfamide injection is a cytotoxic alkylating agent, chemically related to the nitrogen mustards and built as a synthetic analog of cyclophosphamide, supplied as a powder for injection and infused into a vein under oncology supervision. It is a prodrug, which means the vial itself holds an inactive compound. Enzymes in the liver have to convert it before anything happens to a tumor cell.

That conversion is also where the trouble starts, and it is the reason this product is sold as a pack rather than a single vial. It belongs to the cytotoxic side of our oncology product line and is handled accordingly.

Why Mesna Ships in the Same Box

Liver enzymes turn ifosfamide into 4-hydroxyifosfamide, which then splits into two very different things. Isophosphoramide mustard does the therapeutic work, crosslinking DNA inside the tumor cell. Acrolein does nothing useful at all and goes on to irritate the lining of the bladder, which is what causes hemorrhagic cystitis.

The size of that effect is on record rather than assumed. In the trial data behind the label, blood in the urine was reported in 44 percent of patients who did not receive mesna and 21 percent of those who did. That single comparison is why ifosfamide and mesna are packed together, and why a buyer should never treat the mesna as an optional extra to be dropped from an order.

Ifosfamide Mechanism of Action

The active metabolite forms crosslinks between strands of DNA. A cell carrying that damage cannot copy its genetic material cleanly, and it dies rather than divides. Because activation happens in the liver rather than in the vial, liver function and anything competing for the same enzymes affect how much active drug a patient actually sees.

Ifosfamide Uses

Approved labeling is narrow. Ifosfamide for injection IP 1gm with Mesna injection uses are confined to adults, in combination with certain other approved antineoplastic agents, as third-line chemotherapy of germ cell testicular cancer. It is stated here as product information for healthcare professionals and trade buyers rather than as a recommendation for any patient.

Two words in that sentence matter commercially. Third-line means the product sits behind other regimens rather than at the front, and combination means it is never ordered alone. Buyers stocking it are usually stocking a regimen, not a single molecule.

Ifosfamide Dose and the Mesna Protocol

The ifosfamide dose and the ifosfamide mesna protocol built around it are set by the treating oncologist against the label, so no schedule is published here. The structure is worth understanding, even so, because it drives how the pack is consumed. Mesna is not given once and forgotten. It is timed against the ifosfamide infusion and repeated afterward, because acrolein keeps appearing in the urine for hours after the drug has gone in.

Hydration runs alongside it. Labeling calls for extensive hydration of at least two liters of fluid a day, by mouth or by vein, with diuresis encouraged during and immediately after administration. Preparation is straightforward by comparison: the 1 g vial takes 20 mL of sterile water for injection, or bacteriostatic water, shaken until fully dissolved to give 50 mg per mL. The made-up solution is refrigerated and used within 24 hours.

Monitoring is built into the schedule rather than being optional. A urinalysis is done before each dose, and treatment is withheld when microscopic hematuria passes ten red cells per high-power field. Blood counts are checked before and after each cycle.

Ifosfamide Side Effects

The label carries a boxed warning covering four risks, and all four are the reasons this product stays inside specialist units. Myelosuppression can be severe and lead to fatal infection, with the white cell nadir usually falling in the second week after a dose. Encephalopathy can be severe and can kill. Nephrotoxicity can cause renal failure. Urotoxicity, meaning hemorrhagic cystitis, is the one mesna is there to blunt.

Reported Ifosfamide for injection IP 1gm with Mesna injection side effects at a rate of ten percent or more are hair loss at 90 percent, nausea and vomiting at 47 percent, leukopenia at 44 percent, anemia at 38 percent, central nervous system toxicity at 15 percent, and infection at 10 percent, alongside blood in the urine.

The brain effects deserve their own note because they are easy to miss. Confusion, drowsiness, hallucinations, blurred vision, involuntary movements, incontinence, and seizures have all been reported. Symptoms can start within hours or take days, and they can come back after appearing to settle, so care continues until they clear completely. Risk rises with low albumin, impaired kidney function, poor performance status, bulky abdominal or pelvic disease, previous cisplatin, drugs acting on the brain, and alcohol use.

Kidney damage has a long tail as well. Tubular injury has turned up years after treatment finished, which is why follow-up does not stop when the course does.

Storage, Handling, and Goods Inward

Unreconstituted vials are stored between 20 and 25 degrees C and must be protected from anything above 30 degrees C. That upper limit is the one that matters most in Indian distribution, because a consignment left on a loading dock or in an unventilated van in summer can pass it without anyone recording the excursion.

A labeled hypothetical, written as an illustration rather than a case report: a pallet arrives at a hospital store in May, sits by an open shutter for an afternoon while paperwork is cleared, and goes onto the shelf without a temperature check. Nothing looks wrong. Whether the stock is still within its storage conditions is now unknown, which is exactly the situation a data logger in the carton is meant to prevent.

Ifosfamide Brand Name and Own Label Supply

Indian suppliers sell the combination under their own labels, often listed simply as ifosfamide with mesna injection, and the ifosfamide brand name on a carton usually tells you more about the supplier than the formulation. Through third-party manufacturing, the 1 g vial and its mesna reach the market under your brand name, carton, and artwork. Oncology buyers order across regimens, so partners commonly pair it with products such as carboplatin 50 mg and docetaxel injection vial. Our brand name is TOROFAM-M Injection.

Ifosfamide Injection Price in India

The Ifosfamide for injection IP 1gm with Mesna injection Price is MRP ₹838 per pack. Presentation is what moves it, because this is a combination pack rather than a single vial. The ifosfamide vial and the mesna supplied alongside it both sit inside that figure, and Indian packs differ in how much mesna they carry.

Cytotoxic handling at the plant adds to the base, since containment and operator protection apply from dispensing through to packing. Storage below 25°C keeps the pack out of the cold chain, so no refrigerated charge sits on the quote. Batch pricing then depends on the number of packs ordered. Send your monthly requirement for ifosfamide injection, with the pack configuration and the destination market, and the team will come back with current rates.

Ifosfamide Injection Manufacturer in India

Torso Healthcare is a WHO GMP-certified maker of injectables in India, handling cytotoxic products under dedicated precautions alongside the wider oncology range, including gemcitabine 1 g vial. For buyers searching for an Ifosfamide for injection IP 1gm with Mesna injection manufacturer in India, the questions that decide the order are usually batch consistency, documentation, and whether the mesna component is supplied reliably with every pack. A certificate of analysis travels with each batch, and dispatch covers domestic and export markets.

Frequently Asked Questions

Why is mesna given with ifosfamide?

Ifosfamide breaks down into acrolein, which irritates the bladder lining and causes hemorrhagic cystitis. Mesna protects the urinary tract from it. In the trial data behind the label, blood in the urine appeared in 44 percent of patients without mesna and 21 percent with it.

Does mesna treat the cancer as well?

No. Mesna has no antitumor activity of its own. It is a protective agent that sits in the pack purely to reduce urinary toxicity, which is why the ifosfamide vial and the mesna are supplied and used together rather than ordered separately.

How is the 1 g vial reconstituted?

With 20 mL of sterile water for injection or bacteriostatic water for injection, shaken until the powder has fully dissolved, giving 50 mg per mL. The prepared solution is refrigerated and used within 24 hours, and can be diluted further for infusion.

What makes ifosfamide a prodrug?

The compound in the vial is inactive. Cytochrome P450 enzymes in the liver convert it into 4-hydroxyifosfamide, which then yields the active isophosphoramide mustard. Nothing cytotoxic happens until that conversion takes place.

Can the pack be supplied under our own brand?

Yes. The combination is available for third-party manufacturing and PCD franchise supply, carrying your brand name and carton artwork, with batch documentation including a certificate of analysis sent with each consignment.

Hospitals and distributors sourcing ifosfamide injection with mesna in bulk, or building their own-label oncology line, can send their requirements with the quantity and pack needed, and Torso Healthcare will reply with current rates.

Composition, indications, preparation, storage, and safety details on this page follow the approved ifosfamide prescribing information.

Disclaimer: This page is intended for pharmaceutical businesses, trade buyers, and healthcare professionals as product reference information only. It is not an advertisement to the public, not medical advice, and not a recommendation for treatment. Ifosfamide is a prescription cytotoxic medicine and must be prescribed and administered only under qualified medical supervision.