Leucovorin Calcium Injection IP 50mg/5ml Vial

You can get Leucovorin Calcium Injection IP from us as a ready-to-use Leucovorin Calcium Injection IP 50mg/5ml single dose vial, supplied under our TORVEVO-5ML brand. Each milliliter contains calcium folinate equal to 10 mg of folinic acid in water for injection. There is no powder, so your pharmacy draws it up and dilutes it. If the solution is not clear, or you can see particles, do not use that vial.

We keep this product in our oncology range even though it is not cytotoxic. It does rescue and modulation work, which means it is given either to pull a patient back from what another drug is doing to them, or to make that other drug work harder. So it travels with chemotherapy through the same distributors, but your pharmacy needs none of the containment those products demand.

If you are stocking it, read the storage line first. Our formulation holds below 30°C protected from light, so you ship it like anything else on the shelf. The preservative-free calcium folinate that international agencies buy has to sit at 2 to 8°C the whole way. Methylparaben and propylparaben are what buy you that difference. You will find this vial listed with the rest of our oncology injectables.

Leucovorin Calcium Injection IP Uses

Approved labeling covers four situations. Every one of them is supportive or defensive rather than curative:

• Rescue after high-dose methotrexate therapy in osteosarcoma.
• Reducing the toxicity of impaired methotrexate elimination, or of an inadvertent overdose of a folic acid antagonist.
• Megaloblastic anemia caused by folic acid deficiency, where oral treatment is not feasible.
• Use with fluorouracil to prolong survival in the palliative treatment of advanced colorectal cancer.

Our pack says the solution is to be diluted for intravenous and intramuscular use only, and the dose is whatever the treating oncologist decides. Where it goes in as an infusion, labeling caps the rate at 160 mg per minute. One thing surprises buyers who are new to it. Unlike the carboplatin vials it ships beside, leucovorin is not cytotoxic, so your pharmacy needs no containment to handle it.

Leucovorin Calcium Injection IP Side Effects

On its own, the product is tolerated well. Most of what your customers report back belongs to the drug it was paired with:

• With fluorouracil: gastrointestinal toxicity, stomatitis and diarrhea in particular, sometimes severe enough to interrupt a cycle.
• Allergic reactions: rash and urticaria, reported rarely.
• Neurological: seizures or fainting, reported rarely and usually in patients receiving fluoropyrimidines.
• Preservative sensitivity: this is a preserved formulation, so a known paraben allergy rules it out.

Two points sit above that whole list:

• Leucovorin may be harmful or fatal if given intrathecally. It is never administered by that route, including for an overdose of a folic acid antagonist that was itself given intrathecally.
• It is improper therapy for pernicious anemia. In megaloblastic anemia caused by vitamin B12 deficiency, it can correct the blood picture while neurological damage carries on underneath.

Leucovorin Calcium Injection IP Price

The Leucovorin Calcium Injection IP price is MRP 680 INR per vial for our TORVEVO-5ML Injection, listed right now at 580 INR. Most of that figure is the pack rather than the drug. Calcium folinate at 10 mg per milliliter is the cheap part. Amber glass, a sterile filling line and a light protective carton are not.

Your order size moves the rest. The more cartons you take, the lower the figure per vial, and a quantity built for a hospital tender will not price like a trial order. For price related inquiries, contact our sales team with your monthly requirement and the destination market, and we will come back with current rates.

Leucovorin Calcium Injection IP Manufacturer

We are a WHO GMP certified Leucovorin Calcium Injection IP supplier and we fill this solution on our own injectable plant. A preserved aqueous injection is a different job from a lyophilized cytotoxic. Our cost sits in sterile filtration, filling and the light protective pack, not in containment and freeze drying, and that is a large part of why we can quote this one the way we do.

People come to us for this product for one of two reasons. Either your oncology range has no rescue agent in it, or you want a Leucovorin Calcium Injection IP third party manufacturer who will put your artwork on the carton so you do not have to build a plant. We handle both the same way. You confirm the pack, the artwork and the market, and we schedule production against your volume. To open a quote, send us your carton count and where it is going.

Frequently Asked Questions

Is leucovorin the same thing as folinic acid?

Effectively yes. Folinic acid is the active molecule, calcium folinate is the calcium salt of it, and that salt is what sits in the vial. Leucovorin is the older name and most prescriptions still use it. That is why our pack prints calcium folinate while the trade keeps ordering leucovorin.

Does this vial need to be reconstituted before use?

No. Our Leucovorin Calcium Injection IP 5ml pack is already a solution, so there is no powder and no mixing step. The pack directs that it be diluted for intravenous and intramuscular use. That is the main practical difference from the lyophilized 50 mg vials, which have to be made up with a diluent before anything can happen.

Why does this store below 30°C when some leucovorin needs refrigeration?

Because ours is preserved and those are not. Methylparaben and propylparaben hold the solution at room temperature. Preservative free calcium folinate has to move and sit at 2 to 8°C. For you that is the difference between normal warehousing and a validated cold chain on every consignment.

Can we carry our own Leucovorin Calcium Injection IP brand name?

Yes. You can get the vial as TORVEVO-5ML Injection, or under a brand you own with your artwork on the mono carton, through third party supply or franchise distribution. The formulation, the line and our quality release do not change. Only the name on the carton does.

What should we ask a contract manufacturer before placing an order?

Ask what the quality release covers, what documentation travels with each batch, and how artwork gets approved before a run is scheduled. We will answer all three before you commit. A Leucovorin Calcium Injection IP contract manufacturer who gets vague on any of them is worth a second look, and the same questions apply to any cytotoxic manufacturing partner you shortlist.

Disclaimer: This page is written for pharmaceutical companies, distributors, PCD franchise partners and healthcare professionals. The product is for the use of a registered medical practitioner, a hospital, or a laboratory only. The information here supports trade and supply decisions, makes no claim of cure or outcome, and does not replace advice from a qualified doctor.